Curcuminoids inhibit enzymes which participate in the synthesis of inflammatory substances in the body. The natural anti-inflammatory activity of curcuminoids is comparable in strength to steroidal drugs, and such nonsteroidal drugs as indomethacin and phenylbutazone, which have dangerous side effects.Arthritis is caused by continuous inflammation, which is a result from a complex series of actions and/or reactions triggered by the body's immunological response to tissue damage. Moderate inflammation is necessary for the healing process; however, continuous inflammation leads to chronic conditions like arthritis and its associated pain.
In a double-blind, controlled study, three groups of patients received either curcumin (400 mg), the anti-inflammatory prescription drug phenylbutazone (100 mg), or a placebo (250 mg of lactose powder) three times daily for five consecutive days after surgery. They had been admitted for either a hernia condition or an accumulation of fluid in the scrotum. The results: curcumin was just as effective as phenylbutazone in reducing post-operative inflammation.
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